Disease: Steroid Sulfatase Deficiency Disease
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
RASSF1 Q9NS23 Ras association domain family member 1 Enzyme modulator 4.9E-06 0.420 0.808
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PSC Cholangitis, primary sclerosing 0.603 0.731
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MGMT P16455 O-6-methylguanine-DNA methyltransferase 1.2E-07 0.412 0.885
MDM4 O15151 MDM4 regulator of p53 Nucleic acid binding 1.00 0.461 0.808
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
HTC2 hypertrichosis 2 (generalized, congenital) 0.392 0.808
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885
HPGDS O60760 hematopoietic prostaglandin D synthase 1.8E-06 0.388 0.923
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923
GADD45A P24522 growth arrest and DNA damage inducible alpha 4.4E-02 0.526 0.769
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
COL11A2 P13942 collagen type XI alpha 2 chain 0.70 0.435 0.846
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
CHEK1 O14757 checkpoint kinase 1 Kinase 3.1E-08 0.492 0.808